Review of the impact of molecular analysis on the therapy of medulloblastoma
Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
Elsevier,
2023-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated introduction of risk-adjusted therapy. Newer subtyping of MB has the potential to rapidly guide the development of clinical trials that further explore risk-adjusted therapies. This review summarizes recent advances in the molecular characterization of medulloblastoma and evaluates subgroup directed treatment. |
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| Item Description: | 2468-1245 10.1016/j.phoj.2023.05.001 |