Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation

• Main Authors: Hikaru Tsuchiya (Author), Akinori Endo (Author), Yasushi Saeki (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2020-06-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The 26S proteasome is a 2.5-MDa protease complex responsible for the selective and ATP-dependent degradation of ubiquitylated proteins in eukaryotic cells. Proteasome-mediated protein degradation accounts for ~70% of all cellular proteolysis under basal conditions, and thereby any dysfunction can le...