Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages

• Main Authors: Kai-Chen Wu (Author), Nicholas D Condon (Author), Timothy A. Hill (Author), Robert C. Reid (Author), David Fairlie (Author), Junxian Lim (Author)
• Format: Book
• Published: Karger Publishers, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a) that activates the cell surface protein C5a rece...