Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations
Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S. enteritidis, S. typhi, S. typhimurium, S. paratyphi, and S. abor...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2021-11-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_1b1730a2dae54f99bd2132a4ddbe0c4f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yonghui Wang |e author |
| 700 | 1 | 0 | |a Meihui Hou |e author |
| 700 | 1 | 0 | |a Zhaodong Kan |e author |
| 700 | 1 | 0 | |a Guanghui Zhang |e author |
| 700 | 1 | 0 | |a Yunxia Li |e author |
| 700 | 1 | 0 | |a Lei Zhou |e author |
| 700 | 1 | 0 | |a Changfa Wang |e author |
| 245 | 0 | 0 | |a Identification of Novel Type Three Secretion System (T3SS) Inhibitors by Computational Methods and Anti-Salmonella Evaluations |
| 260 | |b Frontiers Media S.A., |c 2021-11-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2021.764191 | ||
| 520 | |a Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S. enteritidis, S. typhi, S. typhimurium, S. paratyphi, and S. abortus equi, and their minimum inhibitory concentrations ranged from 1 to 53 μg/ml. Especially, these compounds showed comparable activity as the of the positive control gatifloxacin towards S. abortus equi. The present results suggest that these new T3SS inhibitors could be used as a potential lead molecule for drug development of anti-Salmonella. | ||
| 546 | |a EN | ||
| 690 | |a type III secretion system inhibitor | ||
| 690 | |a virtual screening | ||
| 690 | |a molecular docking | ||
| 690 | |a Salmonella species | ||
| 690 | |a anti-bacterial activity | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 12 (2021) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2021.764191/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1b1730a2dae54f99bd2132a4ddbe0c4f |z Connect to this object online. |