Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2-28 days after subcutaneous transplantation. The autografts stayed patent. In the al...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Hindawi Limited,
2009-01-01T00:00:00Z.
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| Summary: | The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2-28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P<.0001) and fibroblasts (P=.02) resulted in occlusion of the bronchial lumens (P<.01). Influx of CD4+ (P<.001) and CD8+ (P<.0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P<.01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R=0.456-0.879, P< .05−P<.0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response. |
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| Item Description: | 0962-9351 1466-1861 10.1155/2009/510254 |