Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase

Abstract Background Florid oral papillomatosis is characterized by its tendency to local recurrence that requires multiple treatments, leading to important functional sequelae. Methods We present 74‐year‐old woman with oral florid papillomatosis (OFP) who refused a new surgical treatment, and was tr...

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Main Authors: Pedro Ruiz‐Huertas (Author), Alicia Borrego‐Luque (Author), Pilar Toledano‐Valero (Author), Carolina Manzotti (Author), Ángel Rollón‐Mayordomo (Author)
Format: Book
Published: Wiley, 2022-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Pedro Ruiz‐Huertas  |e author 
700 1 0 |a Alicia Borrego‐Luque  |e author 
700 1 0 |a Pilar Toledano‐Valero  |e author 
700 1 0 |a Carolina Manzotti  |e author 
700 1 0 |a Ángel Rollón‐Mayordomo  |e author 
245 0 0 |a Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase 
260 |b Wiley,   |c 2022-08-01T00:00:00Z. 
500 |a 2057-4347 
500 |a 10.1002/cre2.557 
520 |a Abstract Background Florid oral papillomatosis is characterized by its tendency to local recurrence that requires multiple treatments, leading to important functional sequelae. Methods We present 74‐year‐old woman with oral florid papillomatosis (OFP) who refused a new surgical treatment, and was treated with imiquimod 5% in orabase on alternate days for 16 weeks. Treatment was complemented with application of hyaluronic acid gel. Results There were no side effects to the treatment, nor signs of local recurrence, in the treated area at 2 years of follow‐up. Conclusions After reviewing the literature and according to our knowledge, this is the first published case of oral florid papillomatosis treated topically with imiquimod 5% successfully. Topical treatment with imiquimod 5% in orabase may be a valid alternative for patients with recurrent OFP located in the anterior area of the oral cavity who refuse surgical treatment, although we must closely monitor the patient for the possibility of recurrence or malignant degeneration. 
546 |a EN 
690 |a imiquimod 
690 |a immunotherapy 
690 |a oral florid papillomatosis 
690 |a oral mucosa 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Clinical and Experimental Dental Research, Vol 8, Iss 4, Pp 858-862 (2022) 
787 0 |n https://doi.org/10.1002/cre2.557 
787 0 |n https://doaj.org/toc/2057-4347 
856 4 1 |u https://doaj.org/article/1b46e2d63c1e4682bf1d5bc92f52d293  |z Connect to this object online.