The Acute-Phase Proteins Serum Amyloid A and C Reactive Protein in Transudates and Exudates

• Format: Book
• Published: Hindawi Limited, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>The distinction between exudates and transudates is very important in the patient management. Here we evaluate whether the acute-phase protein serum amyloid A (SAA), in comparison with C reactive protein (CRP) and total protein (TP), can be useful in this discrimination. CRP, SAA, and TP were determined in 36 exudate samples (27 pleural and 9 ascitic) and in 12 transudates (9 pleural and 3 ascitic). CRP, SAA, and TP were measured. SAA present in the exudate corresponded to <mml:math alttext="$10\%$"> <mml:mn>10</mml:mn> <mml:mi>&#x0025;</mml:mi> </mml:math> of the amount found in serum, that is, the exudate/serum ratio (E/S) was <mml:math alttext="$0.10pm 0.13$"> <mml:mn>0.10</mml:mn> <mml:mo>&#x00B1;</mml:mo> <mml:mn>0.13</mml:mn> </mml:math>. For comparison, the exudate/serum ratio for CRP and TP was <mml:math alttext="$0.39pm 0.37$"> <mml:mn>0.39</mml:mn> <mml:mo>&#x00B1;</mml:mo> <mml:mn>0.37</mml:mn> </mml:math> and <mml:math alttext="$0.68pm 0.15$"> <mml:mn>0.68</mml:mn> <mml:mo>&#x00B1;</mml:mo> <mml:mn>0.15</mml:mn> </mml:math>, respectively. There was a strong positive correlation between serum and exudate SAA concentration (<mml:math alttext="$r=$,$0.764; p/lt$,$0.0001$"> <mml:mi>r</mml:mi> <mml:mo>=</mml:mo> <mml:mn>0.764</mml:mn> <mml:mo>;</mml:mo> <mml:mi>p</mml:mi> <mml:mo>&#x003C;</mml:mo> <mml:mn>0.0001</mml:mn> </mml:math>). The concentration of SAA in transudates was low and did not overlap with that found in exudates (0.02-0.21 versus 0.8&#8211;360.5un g/mL). SAA in pleural and ascitic exudates results mainly from leakage of the serum protein via the inflamed membrane. A comparison of the E/S ratio of SAA and CRP points SAA as a very good marker in discriminating between exudates and transudates</p>

Item Description

0962-9351