Cover Image

Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4-22. Quinazolines 2, 3, 4, 5, 7, 10, 15, and 18 reduce the act...

Full description

Saved in:

Bibliographic Details
Main Authors:	Adel S. El-Azab (Author), Alaa A.-M (Author), Silvia Bua (Author), Alessio Nocentini (Author), Ahmed H. Bakheit (Author), Hamad M. Alkahtani (Author), Mohamed M. Hefnawy (Author), Claudiu T. Supuran (Author)
Format:	Book
Published:	Elsevier, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates
by: Marwa G. El-Gazzar, et al.
Published: (2018)

Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides
by: Andrea Angeli, et al.
Published: (2023)

Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
by: Suleyman Akocak, et al.
Published: (2019)

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties
by: Andrea Angeli, et al.
Published: (2019)

Potent carbonic anhydrase I, II, IX and XII inhibition activity of novel primary benzenesulfonamides incorporating bis-ureido moieties
by: Tuba Tekeli, et al.
Published: (2023)

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study
by: Alaa A.-M, et al.
Published: (2020)

Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani
by: Alessio Nocentini, et al.
Published: (2019)

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails
by: Fadi M. Awadallah, et al.
Published: (2018)

Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and in silico study
by: Dina I.A. Othman, et al.
Published: (2023)

Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors
by: Adel S. El-Azab, et al.
Published: (2020)

4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
by: Morteza Abdoli, et al.
Published: (2022)

An overview on the recently discovered iota-carbonic anhydrases
by: Alessio Nocentini, et al.
Published: (2021)

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors
by: Mohammad M. Al-Sanea, et al.
Published: (2019)

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors
by: Khulood H. Oudah, et al.
Published: (2023)

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry
by: Mikhail Krasavin, et al.
Published: (2020)

Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?
by: Alessio Nocentini, et al.
Published: (2023)

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors
by: Adel S. El-Azab, et al.
Published: (2020)

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
by: Sonia Del Prete, et al.
Published: (2020)

Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells
by: Francesco Liguori, et al.
Published: (2022)

Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators
by: Suleyman Akocak, et al.
Published: (2017)

Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships
by: Marialuigia Fantacuzzi, et al.
Published: (2023)

Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
by: Simone Giovannuzzi, et al.
Published: (2022)

Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
by: Simone Giovannuzzi, et al.
Published: (2023)

Coumarins effectively inhibit bacterial α-carbonic anhydrases
by: Simone Giovannuzzi, et al.
Published: (2022)

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
by: Alessio Nocentini, et al.
Published: (2018)

1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases
by: Jekaterina Ivanova, et al.
Published: (2023)

Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study
by: Alaa A.-M, et al.
Published: (2021)

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives
by: Rosaria Gitto, et al.
Published: (2019)

Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae
by: Alessio Nocentini, et al.
Published: (2021)

3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII
by: Aleksandrs Pustenko, et al.
Published: (2023)

Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies
by: Ciro Milite, et al.
Published: (2019)

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms
by: Alessio Nocentini, et al.
Published: (2018)

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies
by: Hossam Nada, et al.
Published: (2022)

Virtual screening of combinatorial library of novel benzenesulfonamides on mycobacterial carbonic anhydrase II
by: Dikant F., et al.
Published: (2016)

Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
by: Benas Balandis, et al.
Published: (2022)

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights
by: Waleed A. Badawi, et al.
Published: (2023)

Inhibition studies of bacterial α-carbonic anhydrases with phenols
by: Simone Giovannuzzi, et al.
Published: (2022)

Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†
by: Yassine Aimene, et al.
Published: (2019)

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators
by: Alessio Nocentini, et al.
Published: (2021)

Carbonic Anhydrases and Metabolism
by: Supuran, Claudiu T.
Published: (2019)