Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

• Main Authors: Adel S. El-Azab (Author), Alaa A.-M (Author), Silvia Bua (Author), Alessio Nocentini (Author), Ahmed H. Bakheit (Author), Hamad M. Alkahtani (Author), Mohamed M. Hefnawy (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4-22. Quinazolines 2, 3, 4, 5, 7, 10, 15, and 18 reduce the act...