PKM2-c-Myc-Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer

• Main Authors: Pian Yu (Author), Ao-xue Li (Author), Xi-sha Chen (Author), Min Tian (Author), Hai-yan Wang (Author), Xin-luan Wang (Author), Yi Zhang (Author), Kuan-song Wang (Author), Yan Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism of PKM2 as a protein kinase regulating breast cancer progression and tamoxifen resistance needs to be further clarified....