Variants of CARD8 in Leishmania guyanensis-cutaneous leishmaniasis and influence of the variants genotypes on circulating plasma cytokines IL-1β, TNFα and IL-8.

• المؤلفون الرئيسيون: Héctor David Graterol Sequera (مؤلف), Josué Lacerda de Souza (مؤلف), José do Espírito Santo Junior (مؤلف), Lener Santos da Silva (مؤلف), Suzana Kanawati Pinheiro (مؤلف), Herllon Karllos Athaydes Kerr (مؤلف), Mara Lúcia Gomes de Souza (مؤلف), Marcus Vinitius de Farias Guerra (مؤلف), Tirza Gabrielle Ramos de Mesquita (مؤلف), Rajendranath Ramasawmy (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2023-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein family (NLR) are intracellular pathogen recognition receptors mediating innate immunity, releasing proinflammatory cytokines IL-1β and IL-18, and promoting pyroptotic cell death, upon sensing pathogenic or endogenous d...