Variants of CARD8 in Leishmania guyanensis-cutaneous leishmaniasis and influence of the variants genotypes on circulating plasma cytokines IL-1β, TNFα and IL-8.

• Main Authors: Héctor David Graterol Sequera (Author), Josué Lacerda de Souza (Author), José do Espírito Santo Junior (Author), Lener Santos da Silva (Author), Suzana Kanawati Pinheiro (Author), Herllon Karllos Athaydes Kerr (Author), Mara Lúcia Gomes de Souza (Author), Marcus Vinitius de Farias Guerra (Author), Tirza Gabrielle Ramos de Mesquita (Author), Rajendranath Ramasawmy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein family (NLR) are intracellular pathogen recognition receptors mediating innate immunity, releasing proinflammatory cytokines IL-1β and IL-18, and promoting pyroptotic cell death, upon sensing pathogenic or endogenous d...