Gastroprotective Effect of <i>Anisomeles indica</i> on Aspirin-Induced Gastric Ulcer in Mice

• Main Authors: Hsiu-Man Lien (Author), Yu-Yen Wang (Author), Mei-Zi Huang (Author), Hui-Yu Wu (Author), Chao-Lu Huang (Author), Chia-Chi Chen (Author), Shao-Wen Hung (Author), Chia-Chang Chen (Author), Cheng-Hsun Chiu (Author), Chih-Ho Lai (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/antiox11122327; 2076-3921
• Keywords: <i>Anisomeles indica</i>; ovatodiolide; aspirin; gastric ulcer; inflammation; Therapeutics. Pharmacology; RM1-950
• Source: Antioxidants, Vol 11, Iss 12, p 2327 (2022)

Gastric ulcers are commonly seen in the upper gastrointestinal tract and may be related to the <i>Helicobacter pylori</i> infection and the use of aspirin, a nonsteroidal anti-inflammatory drug (NSAID). Typically, proton-pump inhibitors (PPIs) are used to treat gastric ulcers; however, adverse effects have emerged following long-term treatment. Natural medicines are used as alternative therapeutic agents in the treatment of gastric ulcers, with few side effects. Despite various reports on the anti-<i>H. pylori</i> and anti-gastric cancer activities of <i>Anisomeles indica</i>, its gastroprotective effect on ulcers remains undetermined. This study investigated the protective effect of <i>A. indica</i> on aspirin-induced gastric ulcers in murine models. Our results show that three fractions of ethanol-extracted <i>A. indica</i> inhibited aspirin-induced gastric injury. Among these, <i>A. indica</i> Fraction 1 was observed to enrich ovatodiolide, which effectively diminished gastric acidity and alleviated aspirin-induced inflammation in the stomach. Our results provide evidence that <i>A. indica</i> could be developed as an effective therapeutic agent for gastroprotective purposes.