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Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes...

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Main Authors: Eduardo GONÇALVES (Author), Daniella Reis Barbosa MARTELLI (Author), Ricardo Della COLETTA (Author), Alexandre Rezende VIEIRA (Author), Antônio Prates CALDEIRA (Author), Hercílio MARTELLI JÚNIOR (Author)
Format: Book
Published: Sociedade Brasileira de Pesquisa Odontológica, 2014-01-01T00:00:00Z.
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Summary:The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher's test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.
Item Description:1807-3107
10.1590/1807-3107BOR-2014.vol28.0056

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