Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

• Main Authors: Eduardo GONÇALVES (Author), Daniella Reis Barbosa MARTELLI (Author), Ricardo Della COLETTA (Author), Alexandre Rezende VIEIRA (Author), Antônio Prates CALDEIRA (Author), Hercílio MARTELLI JÚNIOR (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1807-3107; 10.1590/1807-3107BOR-2014.vol28.0056
• Keywords: Leukemia; Cleft Lip; Cleft Palate; Epidemiology; Neoplasms; Dentistry; RK1-715
• Source: Brazilian Oral Research, Vol 28, Iss 1, Pp 1-3 (2014)

The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher's test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.