Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder
Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRNA co-expression patterns in neuronal-like cells treated with widely prescribed BD medications. The aim was to unveil insights into the complex mechanisms of BD medication...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-04-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_1b7db7b99d394d6a8ba7f29dfa0e8f8f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Trang TT. Truong |e author |
| 700 | 1 | 0 | |a Chiara C. Bortolasci |e author |
| 700 | 1 | 0 | |a Briana Spolding |e author |
| 700 | 1 | 0 | |a Bruna Panizzutti |e author |
| 700 | 1 | 0 | |a Zoe SJ. Liu |e author |
| 700 | 1 | 0 | |a Srisaiyini Kidnapillai |e author |
| 700 | 1 | 0 | |a Mark Richardson |e author |
| 700 | 1 | 0 | |a Laura Gray |e author |
| 700 | 1 | 0 | |a Craig M. Smith |e author |
| 700 | 1 | 0 | |a Olivia M. Dean |e author |
| 700 | 1 | 0 | |a Olivia M. Dean |e author |
| 700 | 1 | 0 | |a Jee Hyun Kim |e author |
| 700 | 1 | 0 | |a Jee Hyun Kim |e author |
| 700 | 1 | 0 | |a Michael Berk |e author |
| 700 | 1 | 0 | |a Michael Berk |e author |
| 700 | 1 | 0 | |a Michael Berk |e author |
| 700 | 1 | 0 | |a Ken Walder |e author |
| 245 | 0 | 0 | |a Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder |
| 260 | |b Frontiers Media S.A., |c 2022-04-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2022.873271 | ||
| 520 | |a Long non-coding RNAs (lncRNAs) may play a role in psychiatric diseases including bipolar disorder (BD). We investigated mRNA-lncRNA co-expression patterns in neuronal-like cells treated with widely prescribed BD medications. The aim was to unveil insights into the complex mechanisms of BD medications and highlight potential targets for new drug development. Human neuronal-like (NT2-N) cells were treated with either lamotrigine, lithium, quetiapine, valproate or vehicle for 24 h. Genome-wide mRNA expression was quantified for weighted gene co-expression network analysis (WGCNA) to correlate the expression levels of mRNAs with lncRNAs. Functional enrichment analysis and hub lncRNA identification was conducted on key co-expressed modules associated with the drug response. We constructed lncRNA-mRNA co-expression networks and identified key modules underlying these treatments, as well as their enriched biological functions. Processes enriched in key modules included synaptic vesicle cycle, endoplasmic reticulum-related functions and neurodevelopment. Several lncRNAs such as GAS6-AS1 and MIR100HG were highlighted as driver genes of key modules. Our study demonstrates the key role of lncRNAs in the mechanism(s) of action of BD drugs. Several lncRNAs have been suggested as major regulators of medication effects and are worthy of further investigation as novel drug targets to treat BD. | ||
| 546 | |a EN | ||
| 690 | |a bipolar disorders | ||
| 690 | |a co-expression network | ||
| 690 | |a WGCNA | ||
| 690 | |a mood stabilizers | ||
| 690 | |a lncRNAs | ||
| 690 | |a treatments | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 13 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2022.873271/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1b7db7b99d394d6a8ba7f29dfa0e8f8f |z Connect to this object online. |