Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies

• Main Authors: Faheem Hyder Pottoo (Author), Mohammed Salahuddin (Author), Firdos Alam Khan (Author), Fadhel Alomar (Author), Marwa Abdullah AL Dhamen (Author), Abrar Fouad Alhashim (Author), Hawra Hussain Alqattan (Author), Mohamed S. Gomaa (Author), Mohammad N. Alomary (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epilepsy is a chronic neurodegenerative disease characterized by multiple seizures, hereto 35% of patients remain poor responders. Phenytoin (PHT; 20 and 40 mg/kg) and thymoquinone (THQ; 40 and 80 mg/kg) were given alone and as a low dose combination for 14 days (p.o), prior to challenge with maxima...