The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes

Anesthetics are essential for cancer surgery, but accumulated research have proven that some anesthetics promote the occurrence of certain cancers, leading to adverse effects in the lives of patients. Although anesthetic technology is mature, there is no golden drug selection standard for surgical c...

Full description

Saved in:
Bibliographic Details
Main Authors: Long Gu (Author), Xueqi Pan (Author), Chongcheng Wang (Author), Lei Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_1b8d97b7f0474c46a5af8f17e0bcc4ff
042 |a dc 
100 1 0 |a Long Gu  |e author 
700 1 0 |a Xueqi Pan  |e author 
700 1 0 |a Chongcheng Wang  |e author 
700 1 0 |a Lei Wang  |e author 
245 0 0 |a The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes 
260 |b Frontiers Media S.A.,   |c 2022-11-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2022.919636 
520 |a Anesthetics are essential for cancer surgery, but accumulated research have proven that some anesthetics promote the occurrence of certain cancers, leading to adverse effects in the lives of patients. Although anesthetic technology is mature, there is no golden drug selection standard for surgical cancer treatment. To afford the responsibility of human health, a more specific regimen for cancer resection is indeed necessary. Immunosuppression in oncologic surgery has an adverse influence on the outcomes of patients. The choice of anesthetic strategies influences perioperative immunity. Among anesthetics, propofol has shown positive effects on immunity. Apart from that, propofol's anticancer effect has been generally reported, which makes it more significant in oncologic surgery. However, the immunoregulative function of propofol is not reorganized well. Herein, we have summarized the impact of propofol on different immunocytes, proposed its potential mechanism for the positive effect on cancer immunity, and offered a conceivable hypothesis on its regulation to postoperative inflammation. We conclude that the priority of propofol is high in oncologic surgery and propofol may be a promising immunomodulatory drug for tumor therapy. 
546 |a EN 
690 |a cancer resection 
690 |a propofol 
690 |a immunocytes 
690 |a inflammation 
690 |a immunomodulation 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pharmacology, Vol 13 (2022) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2022.919636/full 
787 0 |n https://doaj.org/toc/1663-9812 
856 4 1 |u https://doaj.org/article/1b8d97b7f0474c46a5af8f17e0bcc4ff  |z Connect to this object online.