Ultrasound Combined With Microbubbles Loading BDNF Retrovirus to Open Blood-Brain Barrier for Treatment of Alzheimer's Disease

• Main Authors: Feng Wang (Author), Xi-Xi Wei (Author), Lian-Sheng Chang (Author), Lei Dong (Author), Yong-Ling Wang (Author), Na-Na Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Brain-derived nerve growth factor (BDNF) is a promising effective target for the treatment of Alzheimer's disease (AD). BDNF, which has a high molecular weight, has difficulty in crossing the blood-brain barrier (BBB). The study aimed to prepare microbubbles loading brain-derived ne...