Memantine, an antagonist of the NMDA glutamate receptor, affects cell proliferation, differentiation and the intracellular cycle and induces apoptosis in Trypanosoma cruzi.

• Main Authors: Flávia Silva Damasceno (Author), María Julia Barisón (Author), Elisabeth Mieko Furusho Pral (Author), Lisvane Silva Paes (Author), Ariel Mariano Silber (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi and affects approximately 10 million people in endemic areas of Mexico and Central and South America. Currently available chemotherapies are limited to two compounds: Nifurtimox and Benznidazole. Both drugs reduce the symptom...