<i>In-Vitro</i> and <i>In-Vivo</i> Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens

• Main Authors: Megren Bin Faisal Almutairi (Author), Mohammed Alrouji (Author), Yasir Almuhanna (Author), Mohammed Asad (Author), Babu Joseph (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Frankincense (<i>Boswellia sacra</i> oleo gum resin) is reported to possess antimicrobial activity against several pathogens in-vitro. The antimicrobial effects of frankincense oil and its interaction with imipenem and gentamicin against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and multidrug-resistant <i>P. aeruginosa</i> were determined through in-vitro methods and an in-vivo study using a rat pneumonia model. Frankincense oil was subjected to GC-MS analysis to determine the different volatile components. Antibacterial effects against MRSA and MDR-<i>P. aeruginosa</i> was evaluated and its MIC and MBC were determined. For the rat pneumonia model (in-vivo), oil was administered at a dose of 500 mg/kg and 1000 mg/kg followed by determination of CFU in lung tissue and histological studies. Frankincense oil did not show a very potent inhibitory effect against MRSA or MDR-<i>P. aeruginosa</i>; the oil did not affect the zone of inhibition or FIC when combined with imipenem or gentamicin indicating a lack of interaction between the oil and the antibiotics. Furthermore, there was no interaction between the antibiotics and the frankincense oil in the in-vivo model. The result of the study revealed that frankincense oil has a weak inhibitory effect against MRSA and MDR-<i>P. aeruginosa</i>, and it did not show any interaction with imipenem or gentamicin.

Item Description

10.3390/antibiotics11111591
2079-6382