The role of basophils as innate immune regulatory cells in allergy and immunotherapy

Basophils are circulating cells that are associated quite exclusively with allergy response and hypersensitivity reactions but their role in the immune network might be much more intriguing and complex than previously expected. The feasibility of testing their biology in vitro for allergy research a...

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Main Authors: Salvatore Chirumbolo (Author), Geir Bjørklund (Author), Andrea Sboarina (Author), Antonio Vella (Author)
Format: Book
Published: Taylor & Francis Group, 2018-04-01T00:00:00Z.
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100 1 0 |a Salvatore Chirumbolo  |e author 
700 1 0 |a Geir Bjørklund  |e author 
700 1 0 |a Andrea Sboarina  |e author 
700 1 0 |a Antonio Vella  |e author 
245 0 0 |a The role of basophils as innate immune regulatory cells in allergy and immunotherapy 
260 |b Taylor & Francis Group,   |c 2018-04-01T00:00:00Z. 
500 |a 2164-5515 
500 |a 2164-554X 
500 |a 10.1080/21645515.2017.1417711 
520 |a Basophils are circulating cells that are associated quite exclusively with allergy response and hypersensitivity reactions but their role in the immune network might be much more intriguing and complex than previously expected. The feasibility of testing their biology in vitro for allergy research and diagnosis, due fundamentally to their quite easy availability in the peripheral blood, made them the major source for assessing allergy in the laboratory assay, when yet many further cells such as mast cells and eosinophils are much more involved as effector cells in allergy than circulating basophils. Interestingly, basophil numbers change rarely in peripheral blood during an atopic response, while we might yet observe an increase in eosinophils and modification in the biology of mast cells in the tissue during an hypersensitivity response. Furthermore, the fact that basophils are very scanty in numbers suggests that they should mainly serve as regulatory cells in immunity, rather than effector leukocytes, as still believed by the majority of physicians. In this review we will try to describe and elucidate the possible role of these cells, known as "innate IL4-producing cells" in the immune regulation of allergy and their function in allergen immunotherapy. 
546 |a EN 
690 |a basophils 
690 |a immunotherapy 
690 |a t cell 
690 |a immunomodulation 
690 |a t reg 
690 |a allergy 
690 |a immune modulators 
690 |a vaccinology 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Human Vaccines & Immunotherapeutics, Vol 14, Iss 4, Pp 815-831 (2018) 
787 0 |n http://dx.doi.org/10.1080/21645515.2017.1417711 
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787 0 |n https://doaj.org/toc/2164-554X 
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