The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

• Main Authors: Miao-miao Han (Author), Xin-rong Yuan (Author), Xiang Shi (Author), Xing-Yu Zhu (Author), Yue Su (Author), De-Kai Xiong (Author), Xing-Min Zhang (Author), Huan Zhou (Author), Ji-Nian Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.

Item Description

1663-9812
10.3389/fphar.2021.732790