β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G protein activation. The diversity of these sig...
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Elsevier,
2012-01-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Islam A.A.E.-H. Ibrahim |e author |
| 700 | 1 | 0 | |a Hitoshi Kurose |e author |
| 245 | 0 | 0 | |a β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics |
| 260 | |b Elsevier, |c 2012-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.11R10CP | ||
| 520 | |a β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G protein activation. The diversity of these signaling pathways has also been recognized. This leads to an appreciation of β-arrestin-biased agonists, which is a new class of drugs that selectively activate β-arrestin-mediated signaling without G protein activation. In this review, we will discuss the recent advance of β-arrestin-mediated signaling pathways, including a brief account of different biased agonists, their pharmacological applications, and novel β-arrestin research. Keywords:: G protein-coupled receptor, biased agonist, β-arrestin, G protein | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 408-412 (2012) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319305341 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1c11f99d0c4c4d07bfb3b2ecb26c0303 |z Connect to this object online. |