Analysis of human leukocyte antigen genotypes in pemphigus with antidesmoglein antibody profile shift
In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Wolters Kluwer Medknow Publications,
2016-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | In particular pemphigus cases, the phenotypic transition between pemphigus vulgaris and pemphigus foliaceus is observed with the change of antibody profile between anti-desmoglein (Dsg) 3 antibodies and anti-Dsg1 antibodies. In this study, we examined human leukocyte antigen (HLA) genotypes of four pemphigus patients who presented with the phenotypic transition and/or antibody profile shift. Two out of four patients possessed a DRB1*0405-DQB1*0401, and two out of four patients possessed a DRB1*1405-DQB1*0503. These alleles might be associated with the development of phenotypic transition and antibody profile shift. |
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| Item Description: | 1027-8117 10.1016/j.dsi.2016.04.001 |