Insulin resistance in obese children and adolescents

Objective: To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. Methods: Retrospective study of 220 children and adolescents aged 5‐14 years. Anthropometric measurements were performed (weight, height, and waist circ...

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Main Authors: Monica Cristina dos Santos Romualdo (Author), Fernando José de Nóbrega (Author), Maria Arlete Meil Schimith Escrivão (Author)
Format: Book
Published: Brazilian Society of Pediatrics, 2014-11-01T00:00:00Z.
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001 doaj_1c2a942942e243fc8fe98c9bc25b6e3f
042 |a dc 
100 1 0 |a Monica Cristina dos Santos Romualdo  |e author 
700 1 0 |a Fernando José de Nóbrega  |e author 
700 1 0 |a Maria Arlete Meil Schimith Escrivão  |e author 
245 0 0 |a Insulin resistance in obese children and adolescents 
260 |b Brazilian Society of Pediatrics,   |c 2014-11-01T00:00:00Z. 
500 |a 2255-5536 
500 |a 10.1016/j.jpedp.2014.03.006 
520 |a Objective: To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. Methods: Retrospective study of 220 children and adolescents aged 5‐14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinical (gender, age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol, and fractions, triglycerides) data were analyzed. Insulin resistance was identified by the homeostasis model assessment for insulin resistance (HOMA‐IR) index. The analysis of the differences between the variables of interest and the HOMA‐IR quartiles was performed by ANOVA or Kruskal‐Wallis tests. Results: Insulin resistance was diagnosed in 33.20% of the sample. It was associated with low levels of high‐density lipoprotein cholesterol (HDL‐C; p = 0.044), waist circumference measurement (p = 0.030), and the set of clinical and metabolic (p = 0.000) alterations. Insulin‐resistant individuals had higher mean age (p = 0.000), body mass index (BMI; p = 0.000), abdominal circumference (p = 0.000), median triglycerides (p = 0.001), total cholesterol (p ≤ 0.042), and low‐density lipoprotein cholesterol (LDL-C; p ≤ 0.027); and lower HDL‐C levels (p = 0.005). There was an increase in mean BMI (p = 0.000), abdominal circumference (p = 0.000), and median triglycerides (p = 0.002) as the values of HOMA ‐IR increased, with the exception of HDL‐C, which decreased (p = 0.001). Those with the highest number of simultaneous alterations were between the second and third quartiles of the HOMA-IR index (p = 0.000). Conclusion: The results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood. 
546 |a PT 
690 |a Child 
690 |a Adolescent 
690 |a Obesity 
690 |a Insulin resistance 
690 |a Risk factors 
690 |a Metabolic syndrome 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Jornal de Pediatria (Versão em Português), Vol 90, Iss 6, Pp 600-607 (2014) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2255553614001232 
787 0 |n https://doaj.org/toc/2255-5536 
856 4 1 |u https://doaj.org/article/1c2a942942e243fc8fe98c9bc25b6e3f  |z Connect to this object online.