Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp.

• Main Authors: Piyanate Sunyakumthorn (Author), Suwit J Somponpun (Author), Rawiwan Im-Erbsin (Author), Tippawan Anantatat (Author), Kemajittra Jenjaroen (Author), Susanna J Dunachie (Author), Eric D Lombardini (Author), Robin L Burke (Author), Stuart D Blacksell (Author), James W Jones (Author), Carl J Mason (Author), Allen L Richards (Author), Nicholas P J Day (Author), Daniel H Paris (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scrub typhus is an important endemic disease in tropical Asia caused by Orientia tsutsugamushi for which no effective broadly protective vaccine is available. The successful evaluation of vaccine candidates requires well-characterized animal models and a better understanding of the immune response a...