Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies

• Main Authors: Kristina M.J. Aertker (Author), Minu Ravindra Pilvankar (Author), Tobias M. Prass (Author), Michaela Blech (Author), Fabian Higel (Author), Srinath Kasturirangan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTBispecific antibodies (BsAbs) capable of recognizing two distinct epitopes or antigens offer promising therapeutic options for various diseases by targeting multiple pathways. The favorable pharmacokinetic (PK) properties of monoclonal antibodies (mAbs) are crucial, as they directly influenc...