Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1-6, to induce various cellular processes including wound he...
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Hindawi Limited,
2017-01-01T00:00:00Z.
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| 001 | doaj_1c8d7c0688dc45e1a31c44eefac8e0a5 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Silvia Anahi Valdés-Rives |e author |
| 700 | 1 | 0 | |a Aliesha González-Arenas |e author |
| 245 | 0 | 0 | |a Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development |
| 260 | |b Hindawi Limited, |c 2017-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/2017/9173090 | ||
| 520 | |a Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1-6, to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 2017 (2017) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2017/9173090 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1c8d7c0688dc45e1a31c44eefac8e0a5 |z Connect to this object online. |