Cover Image

Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San

Shan Zhang,1 Yujia Lu,1 Wei Chen,2 Wei Shi,1 Qian Zhao,1 Jingjie Zhao,1,3 Li Li1,3 1Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China; 2Experimental and Translational Research Center, Beijing Friendsh...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhang S (Author), Lu Y (Author), Chen W (Author), Shi W (Author), Zhao Q (Author), Zhao J (Author), Li L (Author)
Format:	Book
Published:	Dove Medical Press, 2021-08-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San
by: Zhang S, et al.
Published: (2022)

Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients
by: Ziyi Guo, et al.
Published: (2024)

Network Pharmacology and Experimental Verification: SanQi-DanShen Treats Coronary Heart Disease by Inhibiting the PI3K/AKT Signaling Pathway
by: Zhao M, et al.
Published: (2024)

Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation
by: Sisi Lei, et al.
Published: (2022)

Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy
by: Li Li, et al.
Published: (2023)

Chaihu-Shugan-San ameliorates tumor growth in prostate cancer promoted by depression via modulating sphingolipid and glycerinphospholipid metabolism
by: Wei Li, et al.
Published: (2022)

Chaihu Shugan San ameliorated cognitive deficits through regulating gut microbiota in senescence-accelerated mouse prone 8
by: Zhiyue Li, et al.
Published: (2023)

Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice
by: Xing Wang, et al.
Published: (2019)

Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress
by: Xiaofei Zhu, et al.
Published: (2022)

Chaihu Shugan prevents cholesterol gallstone formation by ameliorating the microbiota dysbiosis and metabolic disturbance in mice
by: Wei Wang, et al.
Published: (2024)

Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway
by: Sisi Lei, et al.
Published: (2024)

Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation
by: Liu Q, et al.
Published: (2024)

Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota
by: Sang-Kap Han, et al.
Published: (2021)

The AMPK-mTOR Pathway Is Inhibited by Chaihu Shugan Powder, Which Relieves Nonalcoholic Steatohepatitis by Suppressing Autophagic Ferroptosis
by: Zheng Liang, et al.
Published: (2024)

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA
by: Chong Ma, et al.
Published: (2022)

Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments
by: Shuhui Wang, et al.
Published: (2022)

Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway
by: Xu Y, et al.
Published: (2021)

Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
by: Jincheng Wang, et al.
Published: (2022)

Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway
by: Wanyun Zuo, et al.
Published: (2021)

Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San in db/db Mice via Activation of PI3K/Akt and AMPK Pathways
by: Bailu Duan, et al.
Published: (2017)

Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease
by: Yanhui Liu, et al.
Published: (2023)

PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
by: Ningning Guo, et al.
Published: (2024)

Targeting EGFR/PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma
by: Jieun Bang, et al.
Published: (2023)

Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: A network pharmacology approach and experimental validation in vitro and in vivo
by: Zhixin Zhan, et al.
Published: (2022)

Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway
by: Yingjun Zhu, et al.
Published: (2020)

Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity
by: Suwei Yan, et al.
Published: (2024)

Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
by: Hu M, et al.
Published: (2018)

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases
by: Amin Iranpanah, et al.
Published: (2023)

UCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway
by: Huang Y, et al.
Published: (2022)

Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease
by: Cai B, et al.
Published: (2024)

Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and experimental investigation
by: Hong Li, et al.
Published: (2022)

PI3K/AKT Pathway and Brain Malformations
by: Gavin B. Rice, et al.
Published: (2015)

Renshen Baidu powder protects ulcerative colitis via inhibiting the PI3K/Akt/NF-κB signaling pathway
by: Zhen Ye, et al.
Published: (2022)

Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture
by: Carmen Terren, et al.
Published: (2021)

Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
by: Yan W, et al.
Published: (2018)

Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway
by: Aixiu Zhou, et al.
Published: (2019)

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases
by: Qian Wang, et al.
Published: (2022)

PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren's Syndrome
by: Ping Zeng, et al.
Published: (2022)

PI3K signalling
by: Martin Turner
Published: (2015)

Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models
by: Zhang B, et al.
Published: (2016)