Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding

• Main Authors: Li-Fang Wang (Author), Yang-Yang Sun (Author), Qian Pan (Author), Yi-Qing Yin (Author), Xiao-Ming Tian (Author), Yue Liu (Author), Tegeleqi Bu (Author), Qingy Zhang (Author), Yong-An Wang (Author), Jing Zhao (Author), Yuan Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung ischemia-reperfusion (IR) injury is induced by pulmonary artery occlusion and reperfusion. Lung IR injury commonly happens after weaning from extracorporeal circulation, lung transplantation, and pulmonary thromboendarterectomy; it is a lethal perioperative complication. A definite therapeutic...