Elastin genetic point mutation and the risk of pelvic organ prolapse
Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exi...
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| Main Authors: | , , , , , |
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| Format: | Book |
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IMR Press,
2020-02-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_1cae6dd0255b447f95e88abe541b4f33 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a N. Haya |e author |
| 700 | 1 | 0 | |a I. Feferkorn |e author |
| 700 | 1 | 0 | |a F. Fares |e author |
| 700 | 1 | 0 | |a N. Azzam |e author |
| 700 | 1 | 0 | |a R. Auslender |e author |
| 700 | 1 | 0 | |a Y. Abramov |e author |
| 245 | 0 | 0 | |a Elastin genetic point mutation and the risk of pelvic organ prolapse |
| 260 | |b IMR Press, |c 2020-02-01T00:00:00Z. | ||
| 500 | |a 0390-6663 | ||
| 500 | |a 10.31083/j.ceog.2020.01.5100 | ||
| 520 | |a Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors hypothesized that a similar association exists between elastin gene polymorphism and POP. Materials and Methods: Patients of Ashkenazi Jewish origin with advanced (stage III-IV) POP (as assessed by POP-Q) and healthy controls were compared for the presence of the elastin gene g28197A > G missense mutation. Results: The missense mutation in the elastin gene was not found in neither the study or the control group. Conclusion: The elastin gene g28197A > G missense mutation was not found to be associated with an increased risk for POP. | ||
| 546 | |a EN | ||
| 690 | |a elastin | ||
| 690 | |a genetic polymorphism | ||
| 690 | |a pelvic organ prolapse | ||
| 690 | |a point mutation | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Clinical and Experimental Obstetrics & Gynecology, Vol 47, Iss 1, Pp 75-78 (2020) | |
| 787 | 0 | |n https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5100 | |
| 787 | 0 | |n https://doaj.org/toc/0390-6663 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1cae6dd0255b447f95e88abe541b4f33 |z Connect to this object online. |