Interpretation of Drug Interaction Using Systemic and Local Tissue Exposure Changes
Systemic exposure of a drug is generally associated with its pharmacodynamic (PD) effect (e.g., efficacy and toxicity). In this regard, the change in area under the plasma concentration-time curve (AUC) of a drug, representing its systemic exposure, has been mainly considered in evaluation of drug-d...
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MDPI AG,
2020-05-01T00:00:00Z.
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