In Vivo Evaluation of Miconazole-Nitrate-Loaded Transethosomal Gel Using a Rat Model Infected with <i>Candida albicans</i>

• Asıl Yazarlar: Zara Asghar (Yazar), Talha Jamshaid (Yazar), Usama Jamshaid (Yazar), Asadullah Madni (Yazar), Naheed Akhtar (Yazar), Manar O. Lashkar (Yazar), Heba A. Gad (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.
• Notes: 10.3390/ph17050546; 1424-8247
• Keywords: miconazole nitrate; antifungal efficacy; transethosomal gel; in vivo evaluation; histopathology; hematology; Medicine; R; Pharmacy and materia medica; RS1-441
• Source: Pharmaceuticals, Vol 17, Iss 5, p 546 (2024)

Miconazole nitrate (MCNR), an antifungal drug, is used to treat superficial infections. The objective of the current study was to assess the antifungal effectiveness of MCNR-loaded transethosomal gel (MNTG) against <i>Candida albicans</i> in an in vivo rat model. The outcomes were compared with those of the miconazole nitrate gel (MNG) and marketed Daktarin^® cream (2%) based on histopathological and hematological studies. The results of the skin irritation test revealed the safety profile of the MNTG. The MNTG demonstrated the greatest antifungal activity in the histological analysis and the visible restoration of the skin, and the rats revealed an apparent evidence of recovery. Compared to the untreated group, the treated group's lymphocyte and white blood cells counts increased, but their eosinophil counts decreased. In conclusion, MNTG exhibited the greatest antifungal activity, which might be connected to the improved skin permeability of the transethosome's nanosized vesicles. Therefore, it could be considered a promising carrier for topical usage and the treatment of cutaneous candidiasis. More clinical research needs to be performed in order to demonstrate its effectiveness and safe usage in humans.