Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis

• Main Authors: Yunzhi Xu (Author), Qi Zhu (Author), Jinglve Song (Author), Hongli Liu (Author), Yutong Miao (Author), Fan Yang (Author), Feiyan Wang (Author), Wenjing Cheng (Author), Yebin Xi (Author), Xiaoyin Niu (Author), Dongyi He (Author), Guangjie Chen (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective. To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. Meth...