Pregnancy outcome in delayed start antagonist versus microdose flare GnRH agonist protocol in poor responders undergoing IVF/ICSI: An RCT
Background: Over the years, many article on different aspects of pathogenesis and management of poor ovarian responders have been published but there is no clear guideline for treating themyet. Objective: This study was designated to compare the effectiveness of a delayed start protocol with gonadot...
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Shahid Sadoughi University of Medical Sciences,
2018-04-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_1cef083d4d1a4f7096d926e4d35e2d07 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Robab Davar |e author |
| 700 | 1 | 0 | |a Nosrat Neghab |e author |
| 700 | 1 | 0 | |a Elham Naghshineh |e author |
| 245 | 0 | 0 | |a Pregnancy outcome in delayed start antagonist versus microdose flare GnRH agonist protocol in poor responders undergoing IVF/ICSI: An RCT |
| 260 | |b Shahid Sadoughi University of Medical Sciences, |c 2018-04-01T00:00:00Z. | ||
| 500 | |a 2476-4108 | ||
| 500 | |a 2476-3772 | ||
| 520 | |a Background: Over the years, many article on different aspects of pathogenesis and management of poor ovarian responders have been published but there is no clear guideline for treating themyet. Objective: This study was designated to compare the effectiveness of a delayed start protocol with gonadotropin-releasing hormone (GnRH) antagonist and microdose flare-up GnRH agonist protocol in poor ovarian responders. Materials and Methods: This randomized clinical trial consisted of 100 poor ovarian responder women in assisted reproductive technologies cycles. They were divided randomly in delayed-start antagonist protocol (with estrogen priming followed by early follicular-phase GnRH antagonist treatment for 7 days before ovarian stimulation) and microdose flare-up GnRH agonist protocol. The main outcome was clinical pregnancy rate and second outcome was the number of retrieved oocytes, mature oocytes, 2PN number, fertilization rate, and implantation rate. Results: Fertilization rate, clinical pregnancy rate, and ongoing pregnancy rates were not significantly different between the two studied protocols. Number of retrieved oocytes (5.10±3.41 vs. 3.08±2.51) with p=0.002, mature oocytes (4.32±2.69 vs. 2.34±1.80) with p=0.003, number of 2PN (3.94±1.80 vs. 2.20±1.01) with p=0.001 and implantation rate (19.40% vs. 10.30%) with p=0.022 were significantly higher in delayed antagonist group. Conclusion: The delayed-start protocol can improve ovarian response in poor responders by stimulating and synchronizing follicle development | ||
| 546 | |a EN | ||
| 690 | |a Infertility | ||
| 690 | |a Assisted reproductive technology | ||
| 690 | |a Gonadotropins | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Reproduction | ||
| 690 | |a QH471-489 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n International Journal of Reproductive BioMedicine, Vol 16, Iss 4, Pp 260-255 (2018) | |
| 787 | 0 | |n http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-567&slc_lang=en&sid=1 | |
| 787 | 0 | |n https://doaj.org/toc/2476-4108 | |
| 787 | 0 | |n https://doaj.org/toc/2476-3772 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1cef083d4d1a4f7096d926e4d35e2d07 |z Connect to this object online. |