A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study

• Main Authors: Angela Roco (Author), Elena Nieto (Author), Marcelo Suárez (Author), Mario Rojo (Author), Maria Paz Bertoglia (Author), Gabriel Verón (Author), Francisca Tamayo (Author), Annabella Arredondo (Author), Daniela Cruz (Author), Jessica Muñoz (Author), Gabriela Bravo (Author), Patricio Salas (Author), Fanny Mejías (Author), Gerald Godoy (Author), Paulo Véliz (Author), Luis Abel Quiñones (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundVitamin K antagonists (VKA) are used as prophylaxis for thromboembolic events in patients with cardiovascular diseases. The most common VKA are warfarin and acenocoumarol. These drugs have a narrow therapeutic margin and high inter-individual response variability due to clinical and pharma...