Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review

• Main Authors: Chen Junren (Author), Xie Xiaofang (Author), Zhang Huiqiong (Author), Li Gangmin (Author), Yin Yanpeng (Author), Cao Xiaoyu (Author), Gao Yuqing (Author), Li Yanan (Author), Zhang Yue (Author), Peng Fu (Author), Peng Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as "Shuizhi" in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess potent anti-thrombotic effect in pr...