Reaction of Proton Pump Inhibitors With Model Peptides Results in Novel Products

• Principais autores: Charles Watson (Autor), Lixin Zhu (Autor), Shenheng Guan (Autor), Terry E. Machen (Autor), John G. Forte (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2013-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The proposed mechanism for proton pump inhibitors (PPIs) is that PPIs are activated at low pH to the sulfenamide form, which reacts with the sulfhydryl group of cysteine(s) at the active site of the proton pump, to produce reducible disulfide-bonded PPI-proton pump conjugates. However, this mechanis...