Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues

• Main Authors: Qun Zhou (Author), Josephine Kyazike (Author), Ekaterina Boudanova (Author), Michael Drzyzga (Author), Denise Honey (Author), Robert Cost (Author), Lihui Hou (Author), Francis Duffieux (Author), Marie-Priscille Brun (Author), Anna Park (Author), Huawei Qiu (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Site-specific antibody conjugations generate homogeneous antibody-drug conjugates with high therapeutic index. However, there are limited examples for producing the site-specific conjugates with a drug-to-antibody ratio (DAR) greater than two, especially using engineered cysteines. Based on availabl...