An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup

Abstract Ethosuximide, the first‐line therapy for childhood absence epilepsy, is currently formulated as a syrup (Zarontin®, Pfizer) with a bitter taste and high sugar content, poorly adapted to children, and a ketogenic diet. The collaborative European FP7 project KIEKIDS aimed at developing an inn...

Disgrifiad llawn

Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Prif Awduron:	Léonore Diezi (Awdur), Kim Dao (Awdur), Vincent Jullien (Awdur), Caroline Roussel‐Maupetit (Awdur), Ingrid Burton (Awdur), Pascal André (Awdur), Carine Bardinet (Awdur), Laura E. Rothuizen (Awdur), Haithem Chtioui (Awdur), Maria A. Manso‐Silvan (Awdur), Catherine Guittet (Awdur), Françoise Brunner‐Ferber (Awdur), Francois Vandenhende (Awdur), Catherine Chiron (Awdur), Luc‐André Granier (Awdur), Thierry Buclin (Awdur)
Fformat:	Llyfr
Cyhoeddwyd:	Wiley, 2023-02-01T00:00:00Z.
Pynciau:	article
Mynediad Ar-lein:	Connect to this object online.
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg

Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!
gan: Pascal André, et al.
Cyhoeddwyd: (2022)

Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers
gan: Kim Dao, et al.
Cyhoeddwyd: (2020)

Ethosuximide-Induced Pseudolymphoma
gan: J Gordon Millichap
Cyhoeddwyd: (2005)

Aplastic Anemia with Ethosuximide
gan: J Gordon Millichap
Cyhoeddwyd: (1994)

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy
gan: J Gordon Millichap
Cyhoeddwyd: (2010)

Ethosuximide vs Valproate Long-term Remission of Absence Epilepsy
gan: J Gordon Millichap, et al.
Cyhoeddwyd: (2014)

Atypical Benign Partial Epilepsy of Childhood Treated with Prednisolone and Ethosuximide
gan: Ji Yeon Lee, et al.
Cyhoeddwyd: (2019)

The Effects of Ethosuximide on Amino Acids in Genetic Absence Epilepsy Rat Model
gan: Berna Terzioğlu, et al.
Cyhoeddwyd: (2006)

Long-Term Effectiveness of Ethosuximide, Valproic Acid and Lamotrigine in Absence Epilepsy
gan: J Gordon Millichap
Cyhoeddwyd: (2012)

Drug-Induced Lupus Secondary to Ethosuximide in Association with Acute Tubulointerstitial Nephritis and Nephrotic Syndrome
gan: Rasha Aly, et al.
Cyhoeddwyd: (2022)

Stevens-Johnson syndrome/toxic epidermal necrolysis overlap triggered by ethosuximide: a rare pediatric report
gan: Sandra Soares-Cardoso, et al.
Cyhoeddwyd: (2023)

A Syrup of the Bees
gan: Bain, F. W. (Francis William), 1863-1940

Ethosuximide Affects Paired-Pulse Facilitation in Somatosensory Cortex of WAG\Rij Rats as a Model of Absence Seizure
gan: Ghazaleh Ghamkhari Nejad, et al.
Cyhoeddwyd: (2015)

The Effect of Oral Consumption of Honey- Saffron syrup with Date syrup on Labor Pain in Nulliparous Women
gan: Hana Sohrabi, et al.
Cyhoeddwyd: (2022)

Severe Raynaud's phenomenon from ethosuximide raised concern over possible onset of systemic vasculitis: a case report
gan: Lillemor Berntson, et al.
Cyhoeddwyd: (2022)

Maple Syrup Disease: Diagnosis and Therapy
gan: J Gordon Millichap
Cyhoeddwyd: (2002)

Production of fructose syrup from tapioca flour
gan: Somboon Supaphon
Cyhoeddwyd: (2014)

Characterization of an eye prosthesis using monopoly syrup
gan: Pinki Bankoti, et al.
Cyhoeddwyd: (2016)

Evaluation of Cardiovascular Safety of Herbal Cough Syrup
gan: Riffat Farooqui, et al.
Cyhoeddwyd: (2024)

Maple Syrup Urine Disease and Cerebral Edema
gan: J Gordon Millichap
Cyhoeddwyd: (1991)

Menkes Maple Syrup Urine Disease: Treatment
gan: J Gordon Millichap
Cyhoeddwyd: (1991)

The use of isoniazid syrup for the prevention of tuberculosis in children.
gan: Liliya Todoriko, et al.
Cyhoeddwyd: (2019)

Atrial fibrillation due to licorice root syrup
gan: Musluhittin Emre Erkuş, et al.
Cyhoeddwyd: (2016)

Case Report: Colchicine Toxicokinetic Analysis in a Poisoned Child Requiring Extracorporeal Life Support
gan: Maria Pérez Marín, et al.
Cyhoeddwyd: (2021)

Comparison of the effects of date syrup with saffron-honey syrup on the progress of labor in nulliparous women: A single blind randomized clinical trial
gan: Hana Sohrabi, et al.
Cyhoeddwyd: (2022)

Upshot of syrup medicines on children's oral health: An appraise
gan: Garima Bhambhani, et al.
Cyhoeddwyd: (2013)

SYRUPS: COMPOSITION, TECHNOLOGY, CURRENT STATE OF RESEARCH (REVIEW)
gan: M. E. Kim, et al.
Cyhoeddwyd: (2015)

EXPERIENCE OF CETIRIZINE SYRUP APPLICATION IN THE ATOPIC ECZEMA IN CHILDREN
gan: F.Ch. Shakhtakhtinskaya
Cyhoeddwyd: (2008)

EXPERIENCE OF CETIRIZINE SYRUP APPLICATION IN THE ATOPIC ECZEMA IN CHILDREN
gan: F.Ch. Shakhtakhtinskaya
Cyhoeddwyd: (2008)

Study of acute and chronic toxicity of homeopathic syrup Stodal
gan: S. V. Alekseeva, et al.
Cyhoeddwyd: (2020)

Maple Syrup Urine Disease Complicated with Kyphoscoliosis and Myelopathy
gan: Jia-Woei Hou
Cyhoeddwyd: (2016)

A comparative study of syrup Trayodashanga Kashaya and syrup Vyaghradi Kashaya along with Anu Taila Nasya in the management of Vataj Pratishyaya W.S.R. to allergic rhinitis
gan: Neetu Singh Siyag, et al.
Cyhoeddwyd: (2023)

Factors associated with stockout of Nevirapine syrup in Oshana Region, Namibia
gan: Emmanuel Magesa, et al.
Cyhoeddwyd: (2020)

The Use of Levocetirizine (L-Cet Syrup) in Children with Allergic Diseases
gan: Yu.V. Marushko, et al.
Cyhoeddwyd: (2015)

Licorice Compound Traditional Syrup: Formulation and Development of Analysis Method
gan: Behnaz Keramatian, et al.
Cyhoeddwyd: (2022)

Formulation and quality control of a poly herbal tranquilizer syrup
Cyhoeddwyd: (2017)

Efficacy of Ambroxol Combined with Loquat Syrup on Bacterial Pneumonia in Mice
gan: Li C, et al.
Cyhoeddwyd: (2024)

A Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial
gan: El-Haggar SM, et al.
Cyhoeddwyd: (2022)

A Potential Role of Ethosuximide and Pentoxifylline in Relieving Abdominal Pain in Irritable Bowel Syndrome Patients Treated with Mebeverine: A Randomized, Double-Blind, Placebo-Controlled Trial [Retraction]
gan: El-Haggar SM, et al.
Cyhoeddwyd: (2022)

Effect of antihistamine-containing syrup on salivary metabolites: an in vitro and in vivo study
gan: Tatiana Kelly da Silva Fidalgo, et al.
Cyhoeddwyd: (2021)