Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

• Main Authors: Francesco Giovacchini (Author), Caterina Bensi (Author), Stefano Belli (Author), Maria Elena Laurenti (Author), Martina Mandarano (Author), Daniele Paradiso (Author), Michele Giansanti (Author), Antonio Tullio (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2212-4268; 10.1016/j.jobcr.2018.11.003
• Keywords: Low-grade intraductal carcinoma; Salivary glands tumor; Low-grade cribriform cystadenocarcinoma; Low-grade salivary duct carcinoma; Systematic review; Dentistry; RK1-715
• Source: Journal of Oral Biology and Craniofacial Research, Vol 9, Iss 1, Pp 96-110 (2019)

Background: Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision. Methods: To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described. Results: Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized. Conclusion: Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.