Prevalence of high-risk <i>human papillomavirus</i> types 16 and 18 in healthy women with cytologically negative pap smear in Iran

• Main Authors: Safaei Akbar (Author), Khanlari Mahsa (Author), Momtahen Moghdeh (Author), Monabati Ahmad (Author), Robati Minoo (Author), Amooei Sedigheh (Author), Valibeigi Behnaz (Author), Azarpira Negar (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<b>Background:</b> Because <i>human papillomavirus</i> (HPV) is one of the causal factors in cervical cancer, understanding the epidemiology of this infection is an important step towards developing strategies for prevention. <b>Materials and Methods:</b> We evaluated the prevalence of high-risk <i>human papillomavirus</i> Types 16 and 18 in cervical samples from 402 healthy women with normal Pap smears by testing with type-specific primers in the polymerase chain reaction. Participants were seen at two gynecological clinics affiliated to the Shiraz University of Medical Sciences in Iran. <b>Result:</b> The prevalence of positive HPV findings was 5.5&#x0025;; high-risk HPV <i>human papillomavirus</i> Type 16 prevalence was 2&#x0025; and no patient harbored HPV-18. The prevalence of HPV was 4.5&#x0025; in younger age group and gradually increased to 20&#x0025; in the 4 ^th decade. <b>Conclusion:</b> The prevalence of high-risk HPV was highest in the youngest women and gradually decreased with age. Overall, the prevalence of HPV in our population is low.

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