Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening

• Main Authors: Ramona Gaa (Author), Hannah Melina Mayer (Author), Daniela Noack (Author), Kavita Kumari (Author), Ralf Guenther (Author), Shang-Pu Tsai (Author), Qingyong Ji (Author), Achim Doerner (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTRecently, there has been a co-evolution of mammalian libraries and diverse microfluidic approaches for therapeutic antibody hit discovery. Mammalian libraries enable the preservation of full immune repertoires, produce hit candidates in final format and facilitate broad combinatorial bispeci...