Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

• Main Authors: Bowen Zhang (Author), Zhenhua Zhang (Author), Valerie A.C.M. Koeken (Author), Saumya Kumar (Author), Michelle Aillaud (Author), Hsin-Chieh Tsay (Author), Zhaoli Liu (Author), Anke R.M. Kraft (Author), Chai Fen Soon (Author), Ivan Odak (Author), Berislav Bošnjak (Author), Anna Vlot (Author), Morris A. Swertz (Author), Uwe Ohler (Author), Robert Geffers (Author), Thomas Illig (Author), Jochen Huehn (Author), Antoine-Emmanuel Saliba (Author), Leif Erik Sander (Author), Reinhold Förster (Author), Cheng-Jian Xu (Author), Markus Cornberg (Author), Leon N. Schulte (Author), Yang Li (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe COVID-19 in some patients and mild COVID-19 in others. Dysfunctional innate immune responses have been identified to contribute to COVID-19 severity, but the key regulators are still unknown. Here, we prese...