Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

• Main Authors: Urve Paaver (Author), Jyrki Heinämäki (Author), Ivan Kassamakov (Author), Tuomo Ylitalo (Author), Edward Hæggström (Author), Ivo Laidmäe (Author), Karin Kogermann (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and polydextrose (PD) were...