Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
<p>Abstract</p> <p>Background</p> <p>Apolipoprotein E (<it>APOE</it>) and elastin (<it>ELN</it>) are plausible candidate genes involved in the pathogenesis of stroke. We tested for association of variants in <it>APOE </it>and <it&g...
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BMC,
2007-07-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Sauerbeck Laura |e author |
| 700 | 1 | 0 | |a Flaherty Matthew |e author |
| 700 | 1 | 0 | |a Kleindorfer Dawn |e author |
| 700 | 1 | 0 | |a Kissela Brett |e author |
| 700 | 1 | 0 | |a Sekar Padmini |e author |
| 700 | 1 | 0 | |a Moomaw Charles |e author |
| 700 | 1 | 0 | |a Xi Huifeng |e author |
| 700 | 1 | 0 | |a Haverbusch Mary |e author |
| 700 | 1 | 0 | |a Pal Prodipto |e author |
| 700 | 1 | 0 | |a Woo Daniel |e author |
| 700 | 1 | 0 | |a Kaushal Ritesh |e author |
| 700 | 1 | 0 | |a Chakraborty Ranajit |e author |
| 700 | 1 | 0 | |a Broderick Joseph |e author |
| 700 | 1 | 0 | |a Deka Ranjan |e author |
| 245 | 0 | 0 | |a Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes |
| 260 | |b BMC, |c 2007-07-01T00:00:00Z. | ||
| 500 | |a 10.1186/1471-2350-8-49 | ||
| 500 | |a 1471-2350 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>Apolipoprotein E (<it>APOE</it>) and elastin (<it>ELN</it>) are plausible candidate genes involved in the pathogenesis of stroke. We tested for association of variants in <it>APOE </it>and <it>ELN </it>with subarachnoid hemorrhage (SAH) in a population-based study. We genotyped 12 single nucleotide polymorphisms (SNPs) on <it>APOE </it>and 10 SNPs on <it>ELN </it>in a sample of 309 Caucasian individuals, of whom 107 are SAH cases and 202 are age-, race-, and gender-matched controls from the Greater Cincinnati/Northern Kentucky region. Associations were tested at genotype, allele, and haplotype levels. A genomic control analysis was performed to check for spurious associations resulting from population substructure.</p> <p>Results</p> <p>At the <it>APOE </it>locus, no individual SNP was associated with SAH after correction for multiple comparisons. Haplotype analysis revealed significant association of the major haplotype (Hap1) in <it>APOE </it>with SAH (<it>p </it>= 0.001). The association stemmed from both the 5' promoter and the 3' region of the <it>APOE </it>gene. <it>APOE </it>ε2 and ε 4 were not significantly associated with SAH. No association was observed for <it>ELN </it>at genotype, allele, or haplotype level and our study failed to confirm previous reports of <it>ELN </it>association with aneurysmal SAH.</p> <p>Conclusion</p> <p>This study suggests a role of the <it>APOE </it>gene in the etiology of aneurysmal SAH.</p> | ||
| 546 | |a EN | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n BMC Medical Genetics, Vol 8, Iss 1, p 49 (2007) | |
| 787 | 0 | |n http://www.biomedcentral.com/1471-2350/8/49 | |
| 787 | 0 | |n https://doaj.org/toc/1471-2350 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1e2d5a8ebdfc4d62a6dca12eb27b0e62 |z Connect to this object online. |