In vitro kinetic study of donepezil N- oxide metabolites

• Egile Nagusiak: Faris T. Abachi (Egilea), Ammar B. Behnan (Egilea), Riyath A. Atto (Egilea)
• Formatua: Liburua
• Argitaratua: University of Mosul, 2011-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: The aim of this study was to examine the metabolism of donepezil via N - oxidation of donepezil HCl in vitro, and the kinetic studies at a temperature similar to that of the human body. Methods: Direct reaction of donepezil with hydrogen peroxide and formic acid at room temperature, the N...