Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

• Main Authors: Yuan Zhang (Author), Zhihua Wang (Author), Xiaoyao Ma (Author), Shengnan Yang (Author), Xueyan Hu (Author), Jin Tao (Author), Yuanyuan Hou (Author), Gang Bai (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival. Recent studies have attempted to prevent the interaction of RAS/GTP with RAS guanine nucleotide exchange factors (GEFs), impair RAS-e...