Intra-socket application of Hyaluronic acid reduces pain and swelling following wisdom teeth removal

Background: Hyaluronic acid (HA) has the potential to promote wound healing. Pain and swelling with trismus are common sequalae post wisdom teeth removal. This study aims to investigate the effectiveness of intra-socket HA solution to reduce these uncomfortable post-operative events. Materials and m...

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Main Authors: Sultana Shuborna Nadia (Author), Khoo Lee Kian (Author), Bhattarai Bishwa Prakash (Author), Chaiyasamut Teeranut (Author), Kiattavorncharoen Sirichai (Author), Pairuchvej Verasak (Author), Wongsirichat Natthamet (Author)
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Published: EDP Sciences, 2022-01-01T00:00:00Z.
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001 doaj_1e4fe90b2f7a4c82baaf76c19f48f3c6
042 |a dc 
100 1 0 |a Sultana Shuborna Nadia  |e author 
700 1 0 |a Khoo Lee Kian  |e author 
700 1 0 |a Bhattarai Bishwa Prakash  |e author 
700 1 0 |a Chaiyasamut Teeranut  |e author 
700 1 0 |a Kiattavorncharoen Sirichai  |e author 
700 1 0 |a Pairuchvej Verasak  |e author 
700 1 0 |a Wongsirichat Natthamet  |e author 
245 0 0 |a Intra-socket application of Hyaluronic acid reduces pain and swelling following wisdom teeth removal 
260 |b EDP Sciences,   |c 2022-01-01T00:00:00Z. 
500 |a 2608-1326 
500 |a 10.1051/mbcb/2021038 
520 |a Background: Hyaluronic acid (HA) has the potential to promote wound healing. Pain and swelling with trismus are common sequalae post wisdom teeth removal. This study aims to investigate the effectiveness of intra-socket HA solution to reduce these uncomfortable post-operative events. Materials and methods: 30 patients underwent bilateral extractions of mandibular wisdom teeth for this study. Intra-socket application of 0.7 ml 20 mg/2 ml HA solution (Hyalgun) with Gel foam as a scaffold in study site versus Gel foam only on control site was conducted via a split mouth study design. Data collection of five facial reference points for swelling and maximum mouth opening was recorded during the pre-operative period and post-operative 2nd and 7th day. The VAS pain score at post-op 1st, 2nd and 3rd day and the number of analgesics for the 7-day post-operative duration were evaluated. Results: The HA group demonstrated statistically significant less swelling, trismus and analgesia consumption on the 2 and 7 days after surgery. VAS scores on day 1, 2 and 3 after surgery (P = 0.05) were significantly less in the HA group compared to the control group. Conclusion: The application of intra-socket HA has a positive effect for reducing postoperative pain and swelling with trismus after the lower third molar intervention (LTMI). 
546 |a EN 
690 |a hyaluronic acid 
690 |a lower 3rd molar surgery 
690 |a post-operative pain 
690 |a swelling 
690 |a trismus 
690 |a Dentistry 
690 |a RK1-715 
690 |a Surgery 
690 |a RD1-811 
655 7 |a article  |2 local 
786 0 |n Journal of Oral Medicine and Oral Surgery, Vol 28, Iss 1, p 14 (2022) 
787 0 |n https://www.jomos.org/articles/mbcb/full_html/2022/01/mbcb200133/mbcb200133.html 
787 0 |n https://doaj.org/toc/2608-1326 
856 4 1 |u https://doaj.org/article/1e4fe90b2f7a4c82baaf76c19f48f3c6  |z Connect to this object online.