Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)
Background/Aims: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. Methods: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-...
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Karger Publishers,
2017-12-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_1e6e8a01e8f04d98a33de1f798cd4514 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Sung Woo Lee |e author |
700 | 1 | 0 | |a Yeong Hoon Kim |e author |
700 | 1 | 0 | |a Wookyung Chung |e author |
700 | 1 | 0 | |a Sue K. Park |e author |
700 | 1 | 0 | |a Dong Wan Chae |e author |
700 | 1 | 0 | |a Curie Ahn |e author |
700 | 1 | 0 | |a Yong-Soo Kim |e author |
700 | 1 | 0 | |a Su Ah Sung |e author |
245 | 0 | 0 | |a Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) |
260 | |b Karger Publishers, |c 2017-12-01T00:00:00Z. | ||
500 | |a 1420-4096 | ||
500 | |a 1423-0143 | ||
500 | |a 10.1159/000485865 | ||
520 | |a Background/Aims: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. Methods: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-2016) and excluded 198 patients with missing data regarding serum hepcidin, hemoglobin, transferrin saturation (TSAT), ferritin, and usage of erythropoiesis-stimulating agents (ESA) or supplemental iron and 363 patients using ESA or supplemental iron. Finally, 1677 patients were included. Results: The mean patient age was 53.5 years, and 65.4% were men. TSAT and serum hepcidin were significantly associated with anemia status, whereas serum ferritin was not, regardless of anemia severity. For patients with an estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m2, a 10% increase of TSAT was associated with hemoglobin <13 g/dL (odds ratio [OR], 0.628; 95% confidence interval [CI], 0.515-0.765; P<0.001) and hemoglobin <11.5 g/dL (OR, 0.672; 95% CI, 0.476-0.950; P=0.024), whereas a 10-ng/mL increase of serum hepcidin was associated with hemoglobin <11.5 g/dL (OR, 1.379; 95% CI, 1.173-1.620; P<0.001) and hemoglobin <10.0 g/dL (OR, 1.360; 95% CI, 1.115-1.659; P=0.002) for patients with eGFR <45 mL/min/1.73 m2 according to multivariate logistic analysis. Conclusions: TSAT was associated with less severe anemia in early CKD patients. Serum hepcidin was associated with more severe anemia in advanced CKD patients. | ||
546 | |a EN | ||
690 | |a Transferrin saturation | ||
690 | |a Ferritin | ||
690 | |a Hepcidin | ||
690 | |a Anemia | ||
690 | |a Severity | ||
690 | |a Dermatology | ||
690 | |a RL1-803 | ||
690 | |a Diseases of the circulatory (Cardiovascular) system | ||
690 | |a RC666-701 | ||
690 | |a Diseases of the genitourinary system. Urology | ||
690 | |a RC870-923 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Kidney & Blood Pressure Research, Vol 42, Iss 6, Pp 1183-1192 (2017) | |
787 | 0 | |n https://www.karger.com/Article/FullText/485865 | |
787 | 0 | |n https://doaj.org/toc/1420-4096 | |
787 | 0 | |n https://doaj.org/toc/1423-0143 | |
856 | 4 | 1 | |u https://doaj.org/article/1e6e8a01e8f04d98a33de1f798cd4514 |z Connect to this object online. |