Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)

Background/Aims: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. Methods: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-...

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Main Authors: Sung Woo Lee (Author), Yeong Hoon Kim (Author), Wookyung Chung (Author), Sue K. Park (Author), Dong Wan Chae (Author), Curie Ahn (Author), Yong-Soo Kim (Author), Su Ah Sung (Author)
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Published: Karger Publishers, 2017-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Sung Woo Lee  |e author 
700 1 0 |a Yeong Hoon Kim  |e author 
700 1 0 |a Wookyung Chung  |e author 
700 1 0 |a Sue K. Park  |e author 
700 1 0 |a Dong Wan Chae  |e author 
700 1 0 |a Curie Ahn  |e author 
700 1 0 |a Yong-Soo Kim  |e author 
700 1 0 |a Su Ah Sung  |e author 
245 0 0 |a Serum Hepcidin and Iron Indices Affect Anemia Status Differently According to the Kidney Function of Non-Dialysis Chronic Kidney Disease Patients: Korean Cohort Study For Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) 
260 |b Karger Publishers,   |c 2017-12-01T00:00:00Z. 
500 |a 1420-4096 
500 |a 1423-0143 
500 |a 10.1159/000485865 
520 |a Background/Aims: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. Methods: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-2016) and excluded 198 patients with missing data regarding serum hepcidin, hemoglobin, transferrin saturation (TSAT), ferritin, and usage of erythropoiesis-stimulating agents (ESA) or supplemental iron and 363 patients using ESA or supplemental iron. Finally, 1677 patients were included. Results: The mean patient age was 53.5 years, and 65.4% were men. TSAT and serum hepcidin were significantly associated with anemia status, whereas serum ferritin was not, regardless of anemia severity. For patients with an estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m2, a 10% increase of TSAT was associated with hemoglobin <13 g/dL (odds ratio [OR], 0.628; 95% confidence interval [CI], 0.515-0.765; P<0.001) and hemoglobin <11.5 g/dL (OR, 0.672; 95% CI, 0.476-0.950; P=0.024), whereas a 10-ng/mL increase of serum hepcidin was associated with hemoglobin <11.5 g/dL (OR, 1.379; 95% CI, 1.173-1.620; P<0.001) and hemoglobin <10.0 g/dL (OR, 1.360; 95% CI, 1.115-1.659; P=0.002) for patients with eGFR <45 mL/min/1.73 m2 according to multivariate logistic analysis. Conclusions: TSAT was associated with less severe anemia in early CKD patients. Serum hepcidin was associated with more severe anemia in advanced CKD patients. 
546 |a EN 
690 |a Transferrin saturation 
690 |a Ferritin 
690 |a Hepcidin 
690 |a Anemia 
690 |a Severity 
690 |a Dermatology 
690 |a RL1-803 
690 |a Diseases of the circulatory (Cardiovascular) system 
690 |a RC666-701 
690 |a Diseases of the genitourinary system. Urology 
690 |a RC870-923 
655 7 |a article  |2 local 
786 0 |n Kidney & Blood Pressure Research, Vol 42, Iss 6, Pp 1183-1192 (2017) 
787 0 |n https://www.karger.com/Article/FullText/485865 
787 0 |n https://doaj.org/toc/1420-4096 
787 0 |n https://doaj.org/toc/1423-0143 
856 4 1 |u https://doaj.org/article/1e6e8a01e8f04d98a33de1f798cd4514  |z Connect to this object online.